n this opening lecture of the Advanced Female HRT Course, Nico Misleh lays the foundation for understanding estrogen dominance through the lens of metabolic health. He explores the impact of xenoestrogens, endocrine-disrupting chemicals, and modern stressors on female hormones—and makes the case for why HRT is an essential tool in today’s world. This session sets the tone for the rest of the course, building on knowledge from the foundational HRT course.